Symposium

The 1st International Symposium of CCII
-Bioinformatics and its application to cancer and other diseases-
January 15 (Fri), 2021

Overview

Modern biology has transitioned into a new dimension.

Classical biochemistry, molecular biology and cell biology can no longer be pursued without sophisticated instrumentation technologies.
Huge amounts of heterogeneous omics data produced by machines, including DNA/RNA sequences, mass spectrometry readouts, image analysis and FACS sorting, have to be weaved together in conjunction with biological phenotypes.

Similarly, the linkage between large scale information and clinical phenotypes requires these advanced information-producing technologies and the ability to reason about data-phenotype relationships in the face of uncertainty, which is addressed in part by the field of Bioinformatics.
The field is emerging to the center stage of biological and clinical research, and is continuing to develop new methodologies to handle the tsunami of information obtained and its required weaving.

The CCII organizes the 1st International Symposium on Bioinformatics to invite many young scientists who are involved in or want to develop next generation biology using large scale data generation and its mathematical analysis.

Date and Time

January 15 (Fri), 2021
9:00-18:00 (JST)

Venue

Online (via Zoom Webinar)

Program

Official Language: English
This symposium consists of the keynote lecture and three sessions.
The three sessions consist of lectures by invited speakers and selected short talks by young scientists.
We call for papers for the short talks.  For details, please see Call for Papers for Short Talks.

Program

Opening Address & Keynote Lecture
Chairperson: Fumihiko Matsuda
9:00-9:10
Opening Address
Tasuku Honjo (Director, Center for Cancer Immunotherapy and Immunobiology, Kyoto University, Japan)
9:10-9:50
Keynote Lecture
Cancer mutations in normal tissues
Seishi Ogawa (Professor, Kyoto University Graduate School of Medicine, Japan)
Session 1: Bioinformatics on Cancer
Chairpersons: Marco A. Marra & Willy Hugo
9:50-10:20
Lecture 1
Towards a Canadian national program for comprehensive genomic profiling of treatment resistant cancers
Marco A. Marra (Director, Canada’s Michael Smith Genome Sciences Centre, BC Cancer & Professor, Faculty of Medicine, University of British Columbia, Canada)
10:20-10:50
Lecture 2
The intratumoral TCR dynamics under immunotherapy vs. targeted therapy
Willy Hugo (Assistant Adjunct Professor, Department of Medicine, University of California Los Angeles, USA)
10:50-11:05 Break
11:05-11:20
Short talk 1
Epigenome dysregulation resulting from NSD1 mutation in head and neck squamous cell carcinoma
Bo Hu (Kyoto University, Japan & McGill University, Canada)
11:20-11:35
Short talk 2
Comparative analyses of cranial and extra-cranial rhabdoid tumours reveal subgroups with cytotoxic T cell infiltration
Hye-Jung E. Chun (Canada’s Michael Smith Genome Sciences Centre, BC Cancer, Canada)
11:35-11:50
Short talk 3
Integrating DNA and RNA sequencing analysis to describe somatic alterations and expression in the HLA gene loci
Katie M. Campbell (University of California Los Angeles, USA)
11:50-12:05
Short talk 4
Single cell RNAseq analyses reveal the cellular heterogeneity and molecular changes of AML/MDS
Maiko Narahara (Daiichi Sankyo Co., Ltd., Japan)
12:05-13:00 Lunch Break
Session 2: Technical Development
Chairpersons: Yasuhiro Murakawa & Joseph Ledsam
13:00-13:30
Lecture 3
A new genomic and computational approach to study human genomic enhancers and its association with diseases
Yasuhiro Murakawa (Professor, Kyoto University Institute for Advanced Study, Japan)
13:30-14:00
Lecture 4
Health and science at Google
Joseph Ledsam (Clinician Scientist, Google Japan, Japan)
14:00-14:30
Lecture 5
A machine learning approach to generate high-quality metabolite and lipid profiles from mass spectrometry data
Shuji Kawaguchi (Associate Professor, Kyoto University Graduate School of Medicine, Japan)
14:30-14:45
Short talk 5
SingleCellHaystack: A clustering-independent method for finding differentially expressed genes in single-cell transcriptome data
Alexis Vandenbon (Kyoto University, Japan)
14:45-15:00
Short talk 6
Development of a statistical variable selection method to identify useful biomarkers in metabolomic profiling
Seri Kitada (Kyoto University, Japan)
15:00-16:00 Break
Session 3: Bioinformatics on Other Diseases
Chairpersons: Matthew Hurles & J.B. Brown
16:00-16:30
Lecture 6
Deciphering the genetic architecture of developmental disorders
Matthew Hurles (Head of Human Genetics, Wellcome Sanger Institute & Honorary Professor of Human Genetics and Genomics, University of Cambridge, UK)
16:30-17:00
Lecture 7
Skills and thought processes that clinicians and experimentalists need to bridge into informatics
J.B. Brown (Adjunct Associate Professor, Kyoto University Center for Cancer Immunotherapy and Immunobiology & Principal Scientist, Boehringer Ingelheim Germany)
17:00-17:15
Short talk 7
Transposable elements reveal inter-individual variability in the human response to influenza infection
Xun Chen (Kyoto University, Japan)
17:15-17:30
Short talk 8
New strategies using unmapped reads to characterize viral sequences in different human populations
Mio Shibata (Kyoto University, Japan & McGill University, Canada)
17:30-17:45
Short talk 9
A genetic landscape of pulmonary fibrosis in Japanese population -Preliminary results-
Tomoko Nakanishi (Kyoto University, Japan & McGill University, Canada)
17:45-17:50
Closing Remarks
Fumihiko Matsuda

Invited Lecturers & Lecture Titles

J.B. Brown
Kyoto University Graduate School of Medicine, Japan & Boehringer Ingelheim, Germany
Skills and Thought Processes that Clinicians and Experimentalists Need to Bridge into Informatics
Willy Hugo
Department of Medicine, University of California Los Angeles, USA
The Intratumoral TCR Dynamics under Immunotherapy vs. Targeted Therapy
Matthew Hurles
Wellcome Sanger Institute & University of Cambridge, UK
Deciphering the Genetic Architecture of Developmental Disorders
Shuji Kawaguchi
Kyoto University Graduate School of Medicine, Japan
A Machine Learning Approach to Generate High-quality Metabolite and Lipid Profiles from Mass Spectrometry Data
Joseph Ledsam
Google Japan, Japan
Health and Science at Google
Marco A. Marra
Canada’s Michael Smith Genome Sciences Centre, BC Cancer & Faculty of Medicine, University of British Columbia, Canada
Towards a Canadian National Program for Comprehensive Genomic Profiling of Treatment Resistant Cancers
Yasuhiro Murakawa
Kyoto University Institute for Advanced Study, Japan
A New Genomic and Computational Approach to Study Human Genomic Enhancers and its Association with Diseases
Seishi Ogawa (Keynote lecture)
Kyoto University Graduate School of Medicine, Japan
Cancer Mutations in Normal Tissues

Call for Papers for Short Talks

Next-generation sequencing technology is most extensively applied in cancer and rare disease studies. In basic cancer research, basic studies aiming to elucidate its molecular mechanisms and clinical application to pinpoint gene mutations to optimize treatment strategies have made enormous progress. In rare disease study areas, it has successfully been applied to pinpoint the causative mutation in Mendelian diseases. However, the diagnostic rate still stays as low as 30~40% of the patients, and further bioinformatics development is required to increase the rate. We are still searching for analysis methods to pick up disease-related genes in "oligogenic disease" efficiently.
In the short talk session, we encourage young researchers to present their genomics/omics research using the latest bioinformatics tools. In particular, identification of their genetic factors leading to a rapid and reliable diagnosis and the development of new bioinformatics algorisms are most welcome.

Applicants are asked to submit a one-page abstract.
Please submit your abstracts by using Abstract Submission Form here.
Abstract Submission Form

In order to upload your abstracts by the Abstract Submission Form, your Google account will be necessary.
For those who wish to submit abstracts without using Google accounts, please contact the secretariat.
060event-ccii@mail2.adm.kyoto-u.ac.jp

Abstracts should be written in English according to the following instructions.
- Times New Roman or a similar font should be used.
- Font size of the text should be 12.
- Your talk title, name and affiliation should be included.
- The length of the main text should be within 400 words.
- The abstract should be submitted in both of Word and PDF formats. The name of the files should be your name.

Deadline of Abstract submission: December 4 (Fri), 2020
Deadline of Abstract submission: December 14 (Mon), 2020 (Deadline extended)
Application closed.

Abstracts will be reviewed by the organizers and the notice of acceptance will be sent only to the successful applicants by December 11 (Fri.)December 21 (Mon), 2020.

The successful applicants are asked to make presentations as speakers in the symposium.
A 10-minute presentation and a 5-minute discussion are allotted for each speaker.

Speakers are asked to operate their slides by themselves and to show the slides to the audience by sharing the screen of Zoom.
Speakers are asked to join the Zoom connection test to be held before the session.
Speakers will receive detailed information for the presentation schedule, for presenting via Zoom and for the connection test later.

Abstracts of successful applicants will be posted on this website.
Please note that the secretariat will edit the documents to unify their appearance on the symposium website.

Registration

Advance registration is required.
Please register from here.
Registration Form

Registration fee: Free
Only registered participants will be able to access the symposium.
The number of participants will be limited to 500 (first-come-first-served-basis).

Deadline of Registration: January 8 (Fri), 2021
Registration closed.

For those who need a certificate of attendance, please contact the secretariat.
The certificate will be issued after confirming your participation to the symposium.

How to Join the Symposium using Zoom

ID & Password to enter the symposium venue will be sent to the registered participants.
We recommend that you download the latest Zoom application to your device in advance.

Organizers

Tasuku Honjo, Director, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine
Fumihiko Matsuda, Director, Center for Genomic Medicine, Kyoto University Graduate School of Medicine
J.B. Brown, Adjunct Associate Professor, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine and Principal Scientist, Boehringer Ingelheim (Germany)

Contact

Secretariat, The 1st International Symposium of CCII
E-mail address: 060event-ccii@mail2.adm.kyoto-u.ac.jp