●免疫グロブリン遺伝子と、クラススイッチ組み換えに関する研究
- 1. Organization of immunoglobulin heavy chain genes and allelic deletion model. Honjo, T. and Kataoka, T. Proc. Natl. Acad. Sci. USA 75 2140-2144 (1978)
- 2. Cloning and complete nucleotide sequence of mouse imunoglobulin g1 chain gene. Honjo, T., Obata, M., Yamawaki-Kataoka, Y., Kataoka, T., Kawakami, T., Takahashi, N. and Mano, Y. Cell 18 559-568 (1979)
- 3. Rearrangement of immunoglobulin g1-chain gene and mechanism for heavy-chain class switch. Kataoka, T., Kawakami, T., Takahashi, N. and Honjo, T. Proc. Natl. Acad. Sci. USA 77 919-923 (1980)
- 4. Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome. Yaoita, Y. and Honjo, T. Nature 286 850-853 (1980)
- 5. Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes. Kataoka, T., Miyata, T. and Honjo, T. Cell 23 357-368 (1981)
- 6. Switch region of the immunoglobulin Cg gene is composed of simple tandem repetitive sequences. Nikaido, T., Nakai, S. and Honjo, T. Nature 292 845-848 (1981)
- 7. Ordering of mouse immunoglobulin heavy chain genes by molecular cloning. Shimizu, A., Takahashi, N., Yamawaki-Kataoka, Y., Nishida, Y., Kataoka, T. and Honjo, T. Nature 289 149-153 (1981)
- 8. Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. Shimizu, A., Takahashi, N., Yaoita, Y. and Honjo, T. Cell 28 499-506 (1982)
- 9. Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. Noma, Y., Sideras, P., Naito, T., Bergstedt-Lindquist, S., Azuma, C., Severinson, E., Tanabe, T., Kinashi, T., Matsuda, F., Yaoita, Y. and Honjo, T. Nature 319 640-646 (1986)
- 10. Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II. Kinashi, T., Harada, N., Severinson, E., Tanabe, T., Sideras, P., Konishi, M., Azuma, C., Tominaga, A., Bergstedt-Lindquist, S., Takahashi, M., Matsuda, F., Yaoita, Y., Takatsu, K. and Honjo. T. Nature 324 70-73 (1986)
- 11. Circular DNA is excised by immunoglobulin class switch recombination. Iwasato, T., Shimizu, A., Honjo, T. and Yamagishi, H. Cell 62 143-149 (1990)
- 12. Signal sequence trap: cloning strategy for secreted proteins and type I membrane proteins. Tashiro, K., Tada, H., Heilker, R., Shirozu, M., Nakano, T. and Honjo, T. Science 261 600-603 (1993)
- 13. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. Matsuda, F., Ishii, K., Bourvagnet, P., Kuma, K., Hayashida, H., Miyata, T. and Honjo, T. J. Exp. Med. 188 2151-2162 (1998)
- 14. Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions. Kinoshita, K., Tashiro, J., Tomita, S., Lee, C-G. and Honjo, T. Immunity 9 849-858 (1998)
- 15. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA editing deaminase family in germinal center B cells. Muramatsu, M., Sankaranand, V. S., Anant, S., Sugai, M., Kinoshita, K., Davidson, N. O. and Honjo, T. J. Biol. Chem. 274 18470-18476 (1999)
- 16. Class switch recombination and hypermutation require activation- induced cytidine deaminase (AID), a potential RNA editing enzyme. Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y. and Honjo, T. Cell 102 553-563 (2000)
- 17. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2). Revy, P., Muto, T., Levy, Y., Geissmann, F., Plebani, A., Sanal, O., Catalan, N., Forveille, M., D.-Lagelouse, R., Gennery, A., Tezcan, I., Ersoy, F., Kayserili, H., Ugazio, A.G., Brousse, N., Muramatsu, M., Notarangelo, L.D., Kinoshita, K., Honjo, T., Fischer, A. and Durandy, A. Cell 102 565-575 (2000)
- 18. AID is required to initiate Nbs 1/??H2AX focus formation and mutations at sites of class switching. Petersen, S., Casellas, R., Reina-S-M, B., Chen, H., Difilippantonio, M., Wilson, P., Hanitsch, L., Celeste, A., Muramatsu, M., Pilch, D., Redon, C., Ried, T., Bonner, W., Honjo, T., Nussenzweig, M. and Nussenzweig, A. Nature 414 660-665 (2001)
- 19. In situ class switching and differentiation to IgA-producing cells in the gut lamina propria. Fagarasan, S., Kinoshita, K., Muramatsu, M., Ikuta, K. and Honjo, T. Nature 413 639-643 (2001)
- 20. Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class switch recombination. Chen, X., Kinoshita, K. and Honjo, T. Proc. Natl. Acad. Sci. USA 98 13860-13865 (2001)
- 21. The AID enzyme induces class switch recombination in fibroblasts. Okazaki, I., Kinoshita, K., Muramatsu, M., Yoshikawa, K. and Honjo, T. Nature 416 340-345 (2002)
- 22. The AID enzyme induces hypermutation in an actively transcribed gene in fibroblasts. Yoshikawa, K., Okazaki, I., Eto, T., Kinoshita, K., Muramatsu, M., Nagaoka, H. and Honjo, T. Science 296 2033-2036 (2002)
- 23. Constitutive expression of AID leads to tumorigenesis. Okazaki, I., Hiai, H., Kakazu, N., Yamada, S., Muramatsu, M., Kinoshita, K. and Honjo, T. J. Exp. Med. 197 1173-1181 (2003)
- 24. AID mutant analyses indicate requirement for class-switch-specific cofactors. Ta, V-T., Nagaoka, H., Catalan, N., Durandy, A., Fischer, A., Imai, K., Nonoyama, S., Tashiro, J., Ikegawa, M., Ito, S., Kinoshita, K., Muramatsu, M. and Honjo, T. Nature Immunol. 4 843-848 (2003)
- 25. Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch. Begum, N. A., Kinoshita, K., Kakazu, N., Muramatsu, M., Nagaoka, H., Shinkura, R., Biniszkiewicz, D., Boyer, L. A., Jaenisch, R. and Honjo, T. Science 305 1160-1163 (2004)
- 26. AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.Kobayashi M, Aida M, Nagaoka H, Begum NA, Kitawaki Y, Nakata M, Stanlie A, Doi T, Kato L, Okazaki IM, Shinkura R, Muramatsu M, Kinoshita K, Honjo T.Proc Natl Acad Sci U S A. 106:22375-80 (2009)
- 27. Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination. Stanlie A, Aida M, Muramatsu M, Honjo T, Begum NA.Proc Natl Acad Sci U S A. 107:22190-5 (2010)
- 28. Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense. Wei M, Shinkura R, Doi Y, Maruya M, Fagarasan S, Honjo T. Nat Immunol. 12:264-70 (2011)
- 29. The AID dilemma: infection, or cancer? Honjo T, Kobayashi M, Begum N, Kotani A, Sabouri S, Nagaoka H. Adv Cancer Res. 113:1-44 (2012)
- 30. Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes. Kato L, Begum NA, Burroughs AM, Doi T, Kawai J, Daub CO, Kawaguchi T, Matsuda F, Hayashizaki Y, Honjo T. Proc Natl Acad Sci U S A. 109 :2479-84 (2012)
- 31. Chromatin reader Brd4 functions in Ig class switching as a repair complex adaptor of nonhomologous end-joining. Stanlie A, Yousif AS, Akiyama H, Honjo T, Begum NA. Mol Cell 55:97-110 (2014)
- 32. Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase. Hu W, Begum NA, Mondal S, Stanlie A, Honjo T. Proc Natl Acad Sci U S A. 112:5791-6 (2015)
- 33. Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability. Husain,A., Begum, NA., Taniguchi, T., Taniguchi, H., Kobayashi, M. and Honjo, T. Nature Communications 7, Article number:10549. doi:10.1038/ncomms10549