Date, Time & Venue
- Date & Time: March 2, 2026 (Mon), 14:00-15:00
- Venue: NITORI Hall, Bristol Myers Squibb Build 1F
- In-person only, admission free
- Organizer: Center for Cancer Immunotherapy and Immunobiology （CCII）
Speaker
Dr. Florent Ginhoux
Laboratory Director, Gustave Roussy(France)
Senior Principal Investigator, SIgN, A*STAR (Singapore)
Abstract
Macrophages have a broad spectrum of immune-and non-immune-related tissue-supporting activities. The roots of this heterogeneity and versatility are only beginning to be understood. Here, we propose a conceptual framework for considering macrophage heterogeneity that organizes the factors shaping their identity within four cardinal points: (1) ontogeny and the view that adult macrophage populations comprise a defined mixture of cells that arise from either embryonic precursors or adult monocytes; (2) local factors unique to the niche of residence, evolving during development and aging; (3) inflammation status; and (4) the cumulative effect of time spent in a specific tissue that contributes to the resilient adaptation of macrophages to their dynamic environment. We will especially discuss how to transpose these concepts to cancer to better understand macrophage heterogeneity.
