The 46th CCII Seminar “Fenestrated capillaries and the sentinel macrophage-nociceptor unit in joint immunity” (Tetsuo Hasegawa)｜Events｜Center for Cancer Immunotherapy and Immunobiology

Date, Time & Venue

Date & Time: March 25, 2026 (Wed) 15:30-16:30
Venue: NITORI Hall, Bristol Myers Squibb Build 1F
In-person only, admission free, no prior registration required
Organizer: Center for Cancer Immunotherapy and Immunobiology （CCII）

Speaker

Dr. Tetsuo Hasegawa

Principal Investigator of Molecular Immunity Unit,
MRC Laboratory of Molecular Biology,
University of Cambridge　　　　　　　

Check here for more details. ＞Hasegawa Lab.

Abstract

Joint inflammation is a common manifestation of systemic immune challenges, yet the anatomical basis for joint sensitivity remains unclear. Using whole-mount imaging of the synovium, we identify fenestrated capillaries localized to the lining–sublininginterface of thelateral synovial compartmentcreating discrete permeable vascular niches. These capillaries permit entry of circulating inflammatory stimuli and are closely associated with specialized macrophage subsets and nociceptor neurons, forming a blood–joint barrier that coordinates immune defense and pain signaling.