A research group led by CCII Program-specific Assistant Professor Yuta Matsuoka and Program-specific Associate Professor Yuki Sugiura of the Multi-Omics Platform, in collaboration with Drs. Yoshinori Katsumata and Nobuhiro Nakamoto of Keio University, and Dr. Kota Iguchi of Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-Kofukai discovered that as ferroptosis progresses, a special substance known as the “iron-smell molecule” is released from cells as a gas.

Yuta Matsuoka
Yuki Sugiura
Multi-Omics Platform

This suggests the possibility of determining the progression of a disease simply by analyzing breath. This research is expected to lead to new diagnostic methods that allow real-time disease monitoring without putting a burden on the body.

This research was published online in the international academic journal, Redox Biology, on September 2, 2025.

Publication details
Journal Name: Redox Biology
Article Title: Monitoring ferroptosis in vivo: Iron-driven volatile oxidized lipids as breath biomarkers  
Publication Date: September 2, 2025
DOI：10.1016/j.redox.2025.103858
URL：https://www.sciencedirect.com/science/article/pii/S2213231725003714?via%3Dihub