第44回CCIIセミナー “Uncovering the Basic Residue-Rich Sequence: from immunoreceptor signaling to immunotherapy” (Chenqi Xu)｜イベント

第44回CCIIセミナー “Uncovering the Basic Residue-Rich Sequence: from immunoreceptor signaling to immunotherapy” (Chenqi Xu)

開催日時 & 会場

2025年11月18日, 15:00-16:00
会場: CCII Bristol Myers Squibb Building, NITORI Hall (1F)
対面型, 参加無料
主催者 : がん免疫総合研究センター (CCII)

演者

Dr. Chenqi Xu

Professor / Deputy Director
Shanghai Institute of Biochemistry and Cell Biology
Chinese Academy of Sciences

概要

The Basic Residue-Rich Sequence (BRS) is a conserved signaling motif widely present in immunoreceptors but remains poorly understood. By forming electrostatic networks with charged lipids and proteins near the membrane, BRS regulates phosphorylation, ubiquitination, condensation, and mechanotransduction. It also coordinates with tyrosine-based motifs to define immunoreceptor function. Evidence from animal and clinical studies shows that harnessing BRS signaling enhances T-cell persistence and sensitivity, unveiling a new avenue for designing next-generation immunotherapies.