CCII 京都大学大学院医学研究科附属 がん免疫総合研究センター

第46回 CCIIセミナー “Fenestrated capillaries and the sentinel macrophage-nociceptor unit in joint immunity” (Tetsuo Hasegawa)

開催日時&会場

演者

Dr. Tetsuo Hasegawa

Principal Investigator of Molecular Immunity Unit,
MRC Laboratory of Molecular Biology
University of Cambridge

詳細はこちら > Hasegawa Lab.

概要

Joint inflammation is a common manifestation of systemic immune challenges, yet the anatomical basis for joint sensitivity remains unclear. Using whole-mount imaging of the synovium, we identify fenestrated capillaries localized to the lining–sublininginterface of thelateral synovial compartmentcreating discrete permeable vascular niches. These capillaries permit entry of circulating inflammatory stimuli and are closely associated with specialized macrophage subsets and nociceptor neurons, forming a blood–joint barrier that coordinates immune defense and pain signaling.

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