開催日時 & 会場

• 2024年5月24日、15:00-16:00
• 会場：メディカルイノベーションセンター
• 対面型, 参加無料
• 主催者 : がん免疫総合研究センター

演者

Prof. Di Yu

Chair in Paediatric Immunotherapy, Professor of Imunology, Director of the Ian Frazer Centre of Children’s Immunotherapy Research
University of Queensland

概要

Ferroptosis is increasingly recognised as a critical non-apoptotic programmed cell death pathway, significantly impacting the homeostasis and functionality of peripheral CD8+ and CD4+ T cells. Our recent studies have revealed that TFH cells, which are crucial in regulating the dynamics of humoral immunity and vaccine response, demonstrate elevated lipid peroxidation and are particularly susceptible to ferroptosis. The enzyme glutathione peroxidase 4 (GPX4), a key scavenger of lipid peroxidation, is essential for TFH cell survival. Moreover, we have pinpointed several metabolic pathways that enhance T cell resistance to ferroptosis, thus modulating both humoral and cellular immunity across animal models and human subjects. These insights underscore the unique influence of ferroptosis in controlling T cell homeostasis and present a promising therapeutic avenue to boost T cell efficacy in vaccination and anti-tumour immunity.