CCII 京都大学大学院医学研究科附属 がん免疫総合研究センター

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  5. 小林 牧 特定准教授

小林 牧 特定准教授
免疫ゲノム医学講座

　

学歴

  • 1991: 筑波大学医学専門学群　卒業 (医師免許取得)
  • 2001: 筑波大学大学院博士課程　卒業　博士（医学取得)（指導教授　山本雅之　教授、分子発生生物学、TARAセンター、筑波大学; 現在: 東北大学大学院分子医化学分野教授、東北メディカルメガバンク機構長）

職歴

  • 1991-1992: 筑波大学附属病院医員、研修医
  • 1992-1993: 茨城県立こども病院医員、研修医
  • 1994-1997: 筑波大学附属病院医員
  • 2001-2004: JSPS-PD博士研究員
  • 2005-2007: JST-ERATO山本環境応答プロジェクト研究員
  • 2008~: 京都大学免疫ゲノム医学

研究内容

主な論文

Maki Kobayashi, Hiroyuki Wakaguri, Masakazu Shimizu, Koichiro Higasa, Fumihiko Matsuda,  Tasuku Honjo. Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase. PNAS USA120: e2216918120 (2023). DOI: https://doi.org/10.1073/pnas.2216918120

Wajid Amin, Shoki Nishio, Tasuku Honjo, Maki Kobayashi. Necessity of HuR/ELAVL1 for activation-induced cytidine deaminase-dependent decrease in topoisomerase 1 in antibody diversification. International Immunology, dxad011 (2023). DOI: https://doi.org/10.1093/intimm/dxad011

Ziwei Yin, Maki Kobayashi, Wenjun Hu, Koichi Higashi, Nasim A. Begum, Ken Kurokawa, Tasuku Honjo. RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase, Proceedings of the National Academy of Sciences, 117(21) 11624-11635, May 26, 2020. DOI: https://doi.org/10.1073/pnas.1921115117

Helena Islam, Maki Kobayashi, Tasuku Honjo. Apurinic/apyrimidinic endonuclease 1 (APE1) is dispensable for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation in the immunoglobulin gene, International Immunology, 31(8) 543-554, Jul 30, 2019. DOI: https://doi.org/10.1093/intimm/dxz028 

Afzal Husain, Nasim A. Begum, Takako Taniguchi, Hisaaki Taniguchi, Maki Kobayashi, Tasuku Honjo. Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability, Nature Communications, 7(1), Apr, 2016. DOI: https://doi.org/10.1038/ncomms10549

Nasim A. Begum, Hithoshi Nagaoka, Maki Kobayashi and Tasuku Honjo. Molecular Mechanism of AID Function. Chapter 18 in Molecular Biology of B cells, Edited by F. Alt, T. Honjo, A. Radbruch and M. Reth. Academic Press, London, UK. 2015. DOI: https://doi.org/10.1016/b978-0-12-397933-9.00018-7

Jianliang Xu, Afzal Husain, Wenjun Hu, Tasuku Honjo and Maki Kobayashi. APE1 is dispensable for S region cleavage but required for its repair in class switch recombination. PNAS USA. 111:17242-7, 2014. DOI: https://doi.org/10.1073/pnas.1420221111

Somayeh Sabouri, Maki Kobayashi, Nasim A. Begum, Jianliang Xu, Kouji Hirota, Tasuku Honjo. C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion. PNAS USA. 111:2253-2258. 2014. DOI: https://doi.org/10.1073/pnas.132405711

Maki Kobayashi, Zahra Sabouri, Somayeh Sabouri, Yoko Kitawaki, Yves Pommier, Takaya Abe, Hiroshi Kiyonari and Tasuku Honjo. Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation. PNAS USA. 108:19305-19310 (2011). DOI: https://doi.org/10.1073/pnas.1114522108

Maki Kobayashi, Masatoshi Aida, Hitoshi Nagaoka, Nasim A. Begum, Yoko Kitawaki, Mikiyo Nakata, Andre Stanlie, Tomomitsu Doi, Lucia Kato, Il-mi Okazaki, Reiko Shinkura, Masamichi Muramatsu, Kazuo Kinoshita, and Tasuku Honjo. AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination. PNAS 106:22375-22380 (2009). DOI: https://doi.org/10.1073/pnas.0911879106

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