CCII 京都大学大学院医学研究科附属 がん免疫総合研究センター

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  5. Nasim Begum 特定准教授

Nasim Begum 特定准教授
免疫ゲノム医学講座

　

ORCID: https://orcid.org/0000-0001-7177-188X

学歴

  • 生命科学学士・修士号、Visva Bharati University、西ベンガル州、インド
  • 生化学の博士号を取得、Indian Institute of Chemical Biology、カルカッタ、インド
  • ポスドク研修: 1. University of Massachusetts Medical Center、米国（がん生物学、遺伝子制御、予後マーカー)、2. 大阪府立成人病センター、日本（自然免疫、アジュバント療法、感染症）

職歴

  • 研究者、Indian Institute of Chemical Biology、カルカッタ、インド
  • 助教授、京都大学大学院医学研究科免疫学・ゲノム医科学講座
  • 准教授、京都大学大学院医学研究科免疫学・ゲノム医科学講座

研究内容

主な論文

Refaat, A. M., Nakata, M., Husain, A., Kosako, H., Honjo, T., Begum, N.A.. HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression. Cell Rep, 42(3), 112284 (2023). DOI: 10.1016/j.celrep.2023.112284

Haque, F., Honjo, T., Begum, N.A.. XLID syndrome gene Med12 promotes Ig isotype switching through chromatin modification and enhancer RNA regulation. Sci Adv, 8(47), eadd1466 (2022). DOI: 10.1126/sciadv.add1466

Begum, N.A., Haque, F., Stanlie, A., Husain, A., Mondal, S., Nakata, M., Taniguchi, T., Taniguchi, H., Honjo, T.. Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition. EMBO J, 40(12), e106393 (2021). DOI: 10.15252/embj.2020106393

Husain, A., Xu, J., Fujii, H., Nakata, M., Kobayashi, M., Wang, J. Y., Rehwinkel, J., Honjo, T., Begum N.A. SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination. EMBO J, 39(15), e102931 (2020). DOI: 10.15252/embj.2019102931

Mondal, S., Begum N.A., Hu, W., & Honjo, T. Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins. Proc Natl Acad Sci U S A, 113(11), E1545-1554 (2016). DOI: 10.1073/pnas.1601678113

Husain, A., Begum N.A., Taniguchi, T., Taniguchi, H., Kobayashi, M., & Honjo, T.. Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability. Nat Commun, 7, 10549 (2016). DOI: 10.1038/ncomms10549

Hu, W., Begum N.A., Mondal, S., Stanlie, A., & Honjo, T. Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase. Proc Natl Acad Sci U S A, 112(18), 5791-5796 (2015). DOI: 10.1073/pnas.1506167112

Stanlie, A., Yousif, A. S., Akiyama, H., Honjo, T., Begum N.A. Chromatin reader Brd4 functions in Ig class switching as a repair complex adaptor of nonhomologous end-joining. Mol Cell, 55(1), 97-110 (2014). DOI: 10.1016/j.molcel.2014.05.018

Stanlie, A., Aida, M., Muramatsu, M., Honjo, T., Begum N.A. Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination. Proc Natl Acad Sci U S A, 107(51), 22190-22195 (2010). DOI: 10.1073/pnas.1016923108

Begum N.A., Kinoshita, K., Kakazu, N., Muramatsu, M., Nagaoka, H., Shinkura, R. Honjo, T. Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch. Science, 305(5687), 1160-1163 (2004). DOI: 10.1126/science.1098444; https://www.nature.com/articles/nri1465; https://www.science.org/doi/abs/10.1126/science.1102692

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